Artificial Intelligence (AI) is fundamentally reshaping nursing informatics across the United States, promising significant advancements in data management, predictive analytics, and patient care. AI-driven algorithms efficiently analyze extensive electronic health records (EHRs), enhancing decision-making, automating routine tasks, and ultimately improving patient outcomes. However, alongside these benefits come critical challenges such as ensuring data privacy, addressing algorithmic biases, and avoiding over-reliance on technology. Nurses are encouraged to embrace AI through ongoing education and collaboration with IT experts, fostering ethical and effective integration into healthcare practices while preserving the human-centric aspects of nursing care.